Obesity has become a major risk factor for the development of chronic diseases such as
insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity …

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …

Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …

An intricate interplay between genetic and environmental factors contributes to the
development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising …

Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic
burden for health care systems. Obesity and diabetes are dual epidemics on the rise and …

Short-chain fatty acids (SCFAs) are considered the key molecular link between gut
microbiota and pathogenesis of Parkinson's disease (PD). However, the role of SCFAs in PD …

Metformin is a widely prescribed medication whose mechanism of action is not completely
defined and whose role in gestational diabetes management remains controversial. In …

Defective implantation is related to pregnancy-associated disorders such as spontaneous
miscarriage, intrauterine fetal growth restriction and others. Several factors proclaimed to be …

Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers,
demonstrating substantial plasticity. Physiological or pathological stimuli can induce …