These practice parameters are an update of the previously-published recommendations
regarding the indications for polysomnography and related procedures in the diagnosis of …

The act of breathing depends on coordinated activity of the respiratory muscles to generate
subatmospheric pressure. This action is compromised by disease states affecting …

The complexity of central breathing disturbances during sleep has become increasingly
obvious. They present as central sleep apnoeas (CSAs) and hypopnoeas, periodic …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

Chronic neuromuscular diseases may affect all major respiratory muscles groups including
inspiratory, expiratory, and bulbar, and respiratory complications are the major cause of …

Although ventilatory failure is the most common cause of death in amyotrophic lateral
sclerosis (ALS) and measurement of respiratory muscle strength (RMS) has been shown to …

Sleep-disordered breathing in neuromuscular diseases is due to an exaggerated reduction
in lung volumes during supine sleep, a compromised physiologic adaptation to sleep, and …

Background: Noninvasive ventilation (NIV) probably improves survival in ALS, but the
magnitude and duration of any improvement in quality of life (QoL) and the optimal criteria …

The management of motor neurone disease (MND) has evolved rapidly over the last two
decades. Although still incurable, MND is not untreatable. From an attitude of nihilism …

Increasing numbers of patients are surviving episodes of prolonged mechanical ventilation
or benefitting from the recent availability of user‐friendly noninvasive ventilators. Although …