The evidence is increasing that left ventricular noncompaction cardiomyopathy as it is
currently defined does not represent a failure of compaction of pre-existing trabecular …

The prevalent view of developmental phenotypic switching holds that phenotype
modifications occurring during critical windows of development are “irreversible”–that is …

Herein, we consider the heart as an organ whose task is to supply blood flow to the tissues.
A brief section on the form and function of the heart sets the stage for more detailed sections …

The existence of common mechanisms regulating organ regeneration is an intriguing
concept. Here we report on a regulatory element that is transiently activated during heart …

Injuries to complex human organs, such as the limbs and the heart, result in pathological
conditions, for which we often lack adequate treatments. While modern regenerative …

Critical windows are periods of developmental susceptibility when the phenotype of an
embryonic, juvenile or adult animal may be vulnerable to environmental fluctuations …

In response to varying environmental and physiological challenges, vertebrates have
evolved complex and often overlapping systems. These systems detect changes in …

The complete division of the atrial cavity by a septum, resulting in a left and right atrium, is
found in many amphibians and all amniotes (reptiles, birds, and mammals). Surprisingly, it is …

In the 1950s, Arthur C. Guyton removed the heart from its pedestal in cardiovascular
physiology by arguing that cardiac output is primarily regulated by the peripheral …

The electrocardiogram (ECG) reveals that heart chamber activation and repolarization are
much faster in mammals and birds compared to ectothermic vertebrates of similar size …