Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and is often
diagnosed at an unresectable advanced stage. Systemic chemotherapy as well as …

The current treatment paradigm for muscle-invasive bladder cancer (MIBC) consists of
cisplatin-based neoadjuvant chemotherapy followed by local definitive therapy, or local …

Chlorogenic acid (CGA) is a naturally occurring non‐flavonoid polyphenol found in green
coffee beans, teas, certain fruits, and vegetables, that exerts antiviral, antitumor …

Conventional chemotherapies remain the mainstay of treatment for many malignancies.
Kidney complications of these therapies are not infrequent and may have serious …

Magnesium is the fourth most abundant cation in the human body, essential for
physiological processes and is the electrolyte with levels commonly deranged in critically ill …

Cisplatin is extensively used and is highly effective in clinical oncology; nevertheless,
nephrotoxicity has severely limited its widespread utility. Isoquercitrin (IQC), a natural …

The antioxidant flavonoid quercetin has been shown to prevent nephrotoxicity in animal
models and in a clinical study and is thus a very promising prophylactic candidate under …

Cisplatin is an anticancer agent with many side effects such as nephrotoxicity, as well as
being widely used in the treatment of many tumor types. Sinapic acid has antioxidant, anti …

In clinical practice, cisplatin is the most commonly used chemotherapy drug to treat a range
of malignancies. Severe ROS-regulated nephrotoxicity, however, restricts its applicability …