Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug
delivery systems are based on the difference between cancer and healthy cells. Currently …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

Cationic polymers are the subject of intense research as non-viral gene delivery systems,
due to their flexible properties, facile synthesis, robustness, and proven gene delivery …

CRISPR/Cas9 genome editing platforms are widely applied as powerful tools in basic
research and potential therapeutics for genome regulation. The appropriate alternative of …

Sequence-specific gene silencing using small interfering RNA (siRNA) is a Nobel prize–
winning technology that is now being evaluated in clinical trials as a potentially novel …

RNA engineering for nanotechnology and medical applications is an exciting emerging
research field. RNA has intrinsically defined features on the nanometre scale and is a …

Small interfering RNAs (siRNAs) technology has emerged as a promising potential
treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential …

The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene
knockdown has attracted considerable attention toward the use of small interfering RNAs …

We have developed a self-assembled nanoparticle (NP) that efficiently delivers small
interfering RNA (siRNA) to the tumor by intravenous (IV) administration. The NP was …