Mitochondria fuse and divide in response to cell demands and environment. Alterations in
mitochondrial dynamics underlie various human diseases, including cancer and neurologic …

Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …

Background: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent
vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that enables …

Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH,
the right ventricle tends to remain adapted to afterload with increased contractility and little …

Although the causal pathomechanisms contributing to remodelling of the pulmonary
vascular bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous …

Rationale: Inflammation and endothelial dysfunction are considered two primary instigators
of pulmonary arterial hypertension (PAH). CD74 is a receptor for the proinflammatory …

Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition
characterised by increased pulmonary arterial pressure, structural changes in the pulmonary …

Background—Pericytes and their crosstalk with endothelial cells are critical for the
development of a functional microvasculature and vascular remodeling. It is also known that …

Until recently, three classes of medical therapy were available for the treatment of pulmonary
arterial hypertension (PAH)—prostanoids, endothelin receptor antagonists and …

Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the
pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial …