The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Mucus clearance is the primary defense mechanism that protects airways from inhaled
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel …

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …

Mucus is tenacious. It sticks to most particles, preventing their penetration to the epithelial
surface. Multiple low-affinity hydrophobic interactions play a major role in these adhesive …

A major role of respiratory mucus is to trap inhaled particles, including pathogens and
environmental particulates, to limit body exposure. Despite the tremendous health …

Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …

Pulmonary defense mechanisms preventing chronic bacterial infection. The lung is depicted
as an inverted funnel, reflecting the relative surface area of distal versus proximal airways …

Current theories of CF pathogenesis predict different predisposing “local environmental”
conditions and sites of bacterial infection within CF airways. Here we show that, in CF …

Background Abnormal homeostasis of the volume of airway surface liquid in patients with
cystic fibrosis is thought to produce defects in mucus clearance and airway defense …