Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Ion transport across the cell membrane mediated by channels and carriers participate in the
regulation of tumour cell survival, death and motility. Moreover, the altered regulation of …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

Glioblastoma (GBM) is the most common and malignant form of primary brain tumor with a
median survival time of 14–16 months in GBM patients. Surgical treatment with …

Cell migration is a central component of the metastatic cascade requiring a concerted action
of ion channels and transporters (migration-associated transportome), cytoskeletal elements …

Profound cell volume changes occur in primary brain tumours as they proliferate, invade
surrounding tissue or undergo apoptosis. These volume changes are regulated by the flux of …

Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …

In contrast to other Classical Transient Receptor Potential TRPC channels the function of
TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain …

Glioblastoma multiforme are highly motile primary brain tumors. Diffuse tissue invasion
hampers surgical resection leading to poor patient prognosis. Recent studies suggest that …