Multimodal fusion in neuroimaging combines data from multiple imaging modalities to
overcome the fundamental limitations of individual modalities. Neuroimaging fusion can …

Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …

Objective Randomized clinical trials have shown that aerobic exercise attenuates motor
symptom progression in Parkinson's disease, but the underlying neural mechanisms are …

Brain glucose metabolism, including glycolysis, the pentose phosphate pathway, and
glycogen turnover, produces ATP for energetic support and provides the precursors for the …

Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not well …

As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

Involvement of the default mode network (DMN) in cognitive symptoms of Parkinson's
disease (PD) has been reported by resting‐state functional MRI (rsfMRI) studies. However …

Background Alterations in the GBA gene (NM_000157. 3) are the most important genetic risk
factor for Parkinson's disease (PD). Biallelic GBA mutations cause the lysosomal storage …

Parkinson's disease (PD) is the second more common neurodegenerative disease with
increasing incidence worldwide associated to the population ageing. Despite increasing …

Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-
instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive …