Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking
luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

In the Guidelines, differentiation between optimal and essential standards were not always
possible, and were made in sections where it was most practical and sensible. The …

Члены Рабочей группы: Арутюнов ГП, Баранова ЕИ, Барбараш ОЛ, Бойцов СА,
Вавилова ТВ, Виллевальде СВ, Галявич АС, Глезер МГ, Гринева ЕН, Гринштейн ЮИ …

Drug combinations, offering increased therapeutic efficacy and reduced toxicity, play an
important role in treating multiple complex diseases. Yet, our ability to identify and validate …

La tarea de elaboración de GPC incluye la creación de herramientas educativas y
programas de implementación de las recomendaciones. Para su implementación, se …

Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Guidelines summarize and evaluate available evidence with the aim of assisting health
professionals in selecting the best management strategies for an individual patient with a …