Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …

The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …

Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D,
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

A complex intracellular signaling governs different cellular responses in inflammation.
Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular …

The second messenger cyclic AMP (cAMP) can either stimulate or inhibit programmed cell
death (apoptosis). Here, we review examples of cell types that show pro‐apoptotic or anti …

Annexin A1 is a mediator of natural and glucocorticoid-induced resolution of inflammation,
with profound effects on neutrophil apoptosis in vivo. This study aimed at assessing whether …

Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the
joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue …

It has been known for several decades that cyclic AMP (cAMP), a prototypical second
messenger, transducing the action of a variety of G-protein-coupled receptor ligands, has …