Recent studies in addition to studies based on whole genome sequencing (WGS) of clinical
isolates of Mycobacterium tuberculosis (MTB) from diverse geographical regions have …

Respiration is a promising target for the development of new antimycobacterial agents, with
a growing number of compounds in clinical development entering this target space …

Molecular and genomic studies have revealed that Mycobacterium tuberculosis Lineage 4
(L4, Euro-American lineage) emerged in Europe before becoming distributed around the …

Background Whole genome sequencing (WGS) has been proposed as a tool for diagnosing
drug resistance in tuberculosis. However, reports of its effectiveness in endemic countries …

Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose
population structure has largely been shaped by the activities of its obligate human host …

Objectives Whole-genome sequencing (WGS) is rarely used for drug resistance testing of
Mycobacterium tuberculosis in high-endemic settings. Here we present the first study from …

Worldwide, studies investigating the relationship between the lineage of Mycobacterium
tuberculosis (MTB) across geographic areas has empowered the “End TB” program and …

Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We
performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 …

Introduction Ethambutol (Emb) is one of the first-line drugs in the standard combination
therapy for tuberculosis; however, due to the rapid increase in Emb resistance among …

Mycobacterium tuberculosis complex (MTBC) is divided into 9 whole genome sequencing
(WGS) lineages. Among them, lineages 1–4 are widely distributed. Multi-drug resistant …