In the human body, the complex biochemical network known as the mevalonate pathway is
responsible for the biosynthesis of all isoprenoids, which consists of a vast array of …

Background In animal models and clinical trials, statins are reported as effective in reducing
cholesterol levels and lowering the risk of cardiovascular diseases. We have aggregated the …

In multi-target drug design (MTD) medicinal chemistry aims to integrate multiple
pharmacophores into a single drug molecule in order to make it active on several molecular …

Abstract Although statins, 3β‐hydroxy‐3β‐methylglutaryl coenzyme A reductase (HMGR)
inhibitors, have revolutionized the management of cardiovascular diseases by lowering …

Drugs affecting more than one target could result in a more efficient treatment of
multifactorial diseases as well as fewer safety concerns, compared to a one-drug one-target …

A number of newly synthesized 2-[4-(hetero) aromatic] phenyl-2-hydroxy-tetrahydro-1, 4-
oxazine derivatives were found to inhibit lipid peroxidation (IC50 of the most potent was 20 …

Atherosclerosis and related heart disease is strongly associated with elevated blood levels
of total (and LDL) cholesterol. Due to the widespread incidence as well as severity of this …

An ever-increasing demand for better drugs, elevated safety standards, and economic
considerations have all led to a dramatic paradigm shift in the way that drugs are being …

Ηypercholesterolemia/hyperlipidemia in conjunction with oxidative stress and inflammatory
processes contribute synergistically to the pathogenesis of atherosclerosis. We hereby …

The antioxidant and anti-inflammatory effects of hexane (HEXA), chloroform (CHLORO),
ethyl acetate (EA) and total alcoholic (T. ALCOH) extracts of Marrubium alysson in …