Migraine is a common and disabling primary headache disorder with a significant
socioeconomic burden. The management of migraine is multifaceted and is generally …

Ergotamine and dihydroergotamine share structural similarities with the adrenergic,
dopaminergic, and serotonergic neurotransmitters. As a result, they have wide‐ranging …

Background: Cluster headache, when compared with migraine or tension-type headache, is
an uncommon form of primary neurovascular headache. However, with a prevalence of …

The authors of the first edition worked together again to revise data for the second edition of
this popular volume. Based at three of the world's leading centers for the study and treatment …

Objective: To determine dosing and side effects of dihydroergotamine as they affect
outcomes in primary headache disorders. Methods: We audited our use of …

Dale showed in 1906 in a seminal work that ergot inhibits the pressor effect of adrenaline.
Stoll at Sandoz isolated ergotamine from ergot in 1918. Based on the belief that migraine …

Dihydroergotamine mesylate (DHE), an ergot alkaloid, has been extensively utilized and
studied in the treatment of episodic and chronic migraine. This article reviews the …

The 5‐hydroxytryptamine (5‐HT) receptor family mediates the effects of several drugs highly
effective in migraine primarily by activating 5‐HT1B, 5‐HT1D, and 5‐HT1F receptors …

Opinion Statement The conceptual shift of our understanding of migraine from a vascular
disorder to a brain disorder has dramatically altered the approach to the development of …

The ergot alkaloids were the first specific antimigraine therapy available. However, with the
advent of the triptans, their use in the treatment of migraine has declined and their role has …