Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

H Zhao, J Zhang, X Cheng, X Nie, B He - Journal of Ovarian Research, 2023 - Springer
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by
chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women …

Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications

E Diamanti-Kandarakis, A Dunaif - Endocrine reviews, 2012 - academic.oup.com
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis

SS Lim, RJ Norman, MJ Davies, LJ Moran - Obesity Reviews, 2013 - Wiley Online Library
While many women with polycystic ovary syndrome (PCOS) are overweight, obese or
centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The …

Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis

SS Lim, MJ Davies, RJ Norman… - Human reproduction …, 2012 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is closely associated with obesity but
the prevalence of obesity varies between published studies. The objective of this research …

Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: a Mendelian randomization study with meta-analysis

LJ Dobbie, B Pittam, SS Zhao, U Alam… - Human …, 2023 - academic.oup.com
STUDY QUESTION What is the influence of body composition during childhood,
adolescence, and adulthood, as well as metabolic parameters, on incident polycystic ovary …

Functional genomics of PCOS: from GWAS to molecular mechanisms

JM McAllister, RS Legro, BP Modi, JF Strauss - Trends in Endocrinology & …, 2015 - cell.com
Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by increased
ovarian androgen biosynthesis, anovulation, and infertility. PCOS has a strong heritable …

Genetics of the polycystic ovary syndrome

G Kosova, M Urbanek - Molecular and cellular endocrinology, 2013 - Elsevier
Polycystic ovary syndrome (PCOS) is a highly complex endocrine disorder, characterized by
hyperandrogenemia, menstrual irregularities and polycystic ovaries. A strong genetic …

[HTML][HTML] Genetic determinants of polycystic ovary syndrome: progress and future directions

MR Jones, MO Goodarzi - Fertility and sterility, 2016 - Elsevier
The field of the genetics of polycystic ovary syndrome (PCOS) has relatively recently moved
into the era of genome-wide association studies. This has led to the discovery of 16 robust …

Genetics of polycystic ovary syndrome

K Mykhalchenko, D Lizneva, T Trofimova… - Expert review of …, 2017 - Taylor & Francis
Introduction: Polycystic ovary syndrome (PCOS) is a hormonal and metabolic disorder
affecting 5 to 20% of reproductive-aged women worldwide that results in androgen excess …

Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS)

M Phylactou, SA Clarke, B Patel… - Clinical …, 2021 - Wiley Online Library
Background Secondary oligo/amenorrhoea occurs in 3%–5% of women of reproductive age.
The two most common causes are polycystic ovary syndrome (PCOS)(2%–13%) and …