Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth
and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …

Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine
nucleosides. PNP insufficiency in humans is paradoxically associated with both …

Differentiation blockade is a hallmark of acute myeloid leukemia (AML). A strategy to
overcome such a blockade is a promising approach against the disease. The lack of …

Introduction Beneficial microorganisms play essential roles in plant growth and induced
systemic resistance (ISR) by releasing signaling molecules. Our previous study obtained the …

Quiescent human hematopoietic stem cells (HSC) are ideal targets for gene therapy
applications due to their preserved stemness and repopulation capacities; however, they …

Adenosine synthase A (AdsA) is a key virulence factor of Staphylococcus aureus, a
dangerous microbe that causes fatal diseases in humans. Together with staphylococcal …

Simple Summary Ample evidence exists connecting dNTP pool dysregulation to cancer and
genomic instability. SAMHD1, the unique dNTP triphosphohydrolase described in humans …

Recent evidence indicates that specific types of nuclear acids, including guanosine and its
derivatives, act as natural ligands for TLR7. This led us to hypothesize that purine …