Small vessel disease: mechanisms and clinical implications
JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2019 - thelancet.com
Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …
hyperintensities and several other common abnormalities (eg, recent small subcortical …
Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment
C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …
known to be associated with dementia caused by vascular factors, hypertension has more …
Hypertension, neurovascular dysfunction, and cognitive impairment
MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …
represents an important risk factor for vascular cognitive impairment and late-life dementia …
Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and …
Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …
cognitive impairment and dementia. While there is considerable overlap between features of …
Attention convolutional neural network for accurate segmentation and quantification of lesions in ischemic stroke disease
Ischemic stroke lesion and white matter hyperintensity (WMH) lesion appear as regions of
abnormally signal intensity on magnetic resonance image (MRI) sequences. Ischemic stroke …
abnormally signal intensity on magnetic resonance image (MRI) sequences. Ischemic stroke …
Extracellular matrix inflammation in vascular cognitive impairment and dementia
GA Rosenberg - Clinical science, 2017 - portlandpress.com
Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic
manifestations of vascular disease related to large vessel strokes and small vessel disease …
manifestations of vascular disease related to large vessel strokes and small vessel disease …
Intracranial hemodynamic relationships in patients with cerebral small vessel disease
Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …
[HTML][HTML] Cerebral small vessel disease–related dementia: more questions than answers
FM Elahi, MM Wang, JF Meschia - Stroke, 2023 - journals.lww.com
Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
Background and Objectives White matter hyperintensities (WMHs) are frequent imaging
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …
[HTML][HTML] Vascular smooth muscle cell dysfunction in neurodegeneration
Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …