Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …
Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
[HTML][HTML] Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis
Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …
generate a disproportionate fraction of blood leukocytes, correlates with higher risk for …
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
MA Evans, K Walsh - Physiological Reviews, 2023 - journals.physiology.org
Somatic mosaicism, the occurrence of multiple genetically distinct cell clones within the
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
same tissue, is an evitable consequence of human aging. The hematopoietic system is no …
Germline risk of clonal haematopoiesis
Clonal haematopoiesis (CH) is a common, age-related expansion of blood cells with
somatic mutations that is associated with an increased risk of haematological malignancies …
somatic mutations that is associated with an increased risk of haematological malignancies …
Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease
We sought to determine the relationship between age-related clonal hematopoiesis (CH)
and chronic kidney disease (CKD). CH, defined as mosaic chromosome abnormalities …
and chronic kidney disease (CKD). CH, defined as mosaic chromosome abnormalities …
Association of diet quality with prevalence of clonal hematopoiesis and adverse cardiovascular events
Importance Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of
somatic leukemogenic variations in hematopoietic stem cells, has been associated with …
somatic leukemogenic variations in hematopoietic stem cells, has been associated with …
Cardiovascular disease among persons living with HIV: new insights into pathogenesis and clinical manifestations in a global context
M Ntsekhe, JV Baker - Circulation, 2023 - Am Heart Assoc
Widespread use of contemporary antiretroviral therapy globally has transformed HIV
disease into a chronic illness associated with excess risk for disorders of the heart and …
disease into a chronic illness associated with excess risk for disorders of the heart and …
Biological ageing with HIV infection: evaluating the geroscience hypothesis
Although people with HIV are living longer, as they age they remain disproportionately
burdened with multimorbidity that is exacerbated in resource-poor settings. The geroscience …
burdened with multimorbidity that is exacerbated in resource-poor settings. The geroscience …
Clonal hematopoiesis: from mechanisms to clinical intervention
T Köhnke, R Majeti - Cancer discovery, 2021 - AACR
Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …