Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Opioid drugs play important roles in the clinical management of pain, as well as in the
development and treatment of drug abuse. The mu opioid receptor is the primary site of …

K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

A member of the inwardly rectifying potassium channel family was cloned here. The
channel, called BIR (Kir6. 2), was expressed in large amounts in rat pancreatic islets and …

Inward rectifier K+ channels, which modulate electrical activity in many cell types, are
regulated by protein kinases,, guanine-nucleotide-binding proteins (G proteins),,, and …

The principal inhibitory neurotransmitter GABA (γ-aminobutyric acid) exerts its effects
through two ligand-gated channels, GABAA and GABAC receptors, and a third receptor …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium
(K+) channel, IKACh. Activated muscarinic receptors stimulate lKAch via the G-protein βγ …

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels* | Endocrine
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