[HTML][HTML] The systemic nature of CKD

C Zoccali, R Vanholder, ZA Massy, A Ortiz… - Nature Reviews …, 2017 - nature.com
The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Hypoxia-inducible factor activators in renal anemia: current clinical experience

NS Sanghani, VH Haase - Advances in chronic kidney disease, 2019 - Elsevier
Prolyl hydroxylase domain oxygen sensors are dioxygenases that regulate the activity of
hypoxia-inducible factor (HIF), which controls renal and hepatic erythropoietin production …

[HTML][HTML] The renal pathology of obesity

N Tsuboi, Y Okabayashi, A Shimizu, T Yokoo - Kidney international reports, 2017 - Elsevier
Obesity causes various structural, hemodynamic, and metabolic alterations in the kidney.
Most of these are likely to be compensatory responses to the systemic increase in metabolic …

HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

VH Haase - Hemodialysis international, 2017 - Wiley Online Library
A classic response to systemic hypoxia is the increase in red blood cell production. This
response is controlled by the prolyl hydroxylase domain/hypoxia‐inducible factor (HIF) …

[HTML][HTML] Pulmonary hypertension in patients with chronic and end-stage kidney disease

ME Sise, AM Courtwright, RN Channick - Kidney international, 2013 - Elsevier
Pulmonary hypertension is defined as a mean pulmonary artery pressure≥ 25 mm Hg and
is a recently recognized complication of chronic kidney disease and end-stage renal …

Pulmonary hypertension, mortality, and cardiovascular disease in CKD and ESRD patients: a systematic review and meta-analysis

M Tang, JA Batty, C Lin, X Fan, KE Chan… - American journal of kidney …, 2018 - Elsevier
Background Pulmonary hypertension is common in patients with chronic kidney disease
(CKD) and end-stage renal disease (ESRD) and may be associated with poor outcomes …

[HTML][HTML] Pulmonary hypertension surveillance: United States, 2001 to 2010

MG George, LJ Schieb, C Ayala, A Talwalkar, S Levant - Chest, 2014 - Elsevier
Pulmonary hypertension (PH) is an uncommon but progressive condition, and much of what
we know about it comes from specialized disease registries. With expanding research into …

Prevalence, predictors, and outcomes of pulmonary hypertension in CKD

SD Navaneethan, J Roy, K Tao… - Journal of the …, 2016 - journals.lww.com
Pulmonary hypertension (PH) is associated with poor outcomes in the dialysis and general
populations, but its effect in CKD is unclear. We evaluated the prevalence and predictors of …

Cardiac complications of arteriovenous fistulas in patients with end-stage renal disease

M Alkhouli, P Sandhu, K Boobes, K Hatahet… - Nefrología …, 2015 - SciELO Espana
Cardiovascular disease is the leading cause of the death in dialysis patients. Arteriovenous
fistulas (AVFs) are associated with lower mortality and are viewed as the desired access …

Diagnosis and management of pulmonary hypertension in patients with CKD

CP Walther, V Nambi, NA Hanania… - American Journal of …, 2020 - Elsevier
Pulmonary hypertension (PH) is a highly prevalent and important condition in adults with
chronic kidney disease (CKD). In this review, we summarize the definition of PH, discuss its …