Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

A cardinal feature of systemic lupus erythematosus (SLE) is the development of
autoantibodies. The first autoantibodies described in patients with SLE were those specific …

We previously showed that type I interferon-induced, Cre-mediated ablation of surface BCR
expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these …

B cell maturation is a very selective process that requires finely tuned differentiation and
survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member …

Although immature/transitional peripheral B cells may remain susceptible to selection
pressures before full maturation, the nature and timing of these selection events remain …

When I was a young medical student, an interesting discus-sion was going on about how
antibody diversity was encoded; was the antibody molecule encoded in many genes, one for …

Transitional B cells mark the crucial link between bone-marrow (BM) immature and
peripheral mature B cells. Examination reveals unexpected heterogeneity, consisting of …

Purpose Autoantibody production is a characteristic of most autoimmune diseases including
rheumatoid arthritis (RA), but the stage of B-cell development at which B-cell tolerance is …