Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …

The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Native chemical ligation (NCL) provides a highly efficient and robust means to
chemoselectively link unprotected peptide and protein segments to generate proteins. The …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Coming together: A generally applicable strategy for convergent chemical synthesis of
proteins from multiple peptide segments is developed on the basis of the ligation of peptide …

This review summarizes the use of orthogonal dynamic covalent bonds to build functional
systems. Dynamic covalent bonds are unique because of their dual nature. They can be as …

The broad utility of native chemical ligation (NCL) in protein synthesis has fostered a search
for methods that enable the efficient synthesis of C-terminal peptide-thioesters, key …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

Incremental developments in the chemistry of peptides, proteins and carbohydrates have
enabled researchers to assemble entire glycoproteins with high precision. Based on …