Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …

Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

While emerging evidence suggests that neuroinflammation plays a crucial role in
Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a …

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral
role in central nervous system (CNS) development, immune surveillance and repair. The …

Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Although substantial evidence has established that microglia and astrocytes play a key role
in the establishment and maintenance of persistent pain in animal models, the role of glial …

The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …

Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

[11C] PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron
emission tomography (PET) to detect microglial activation. However, quantitative …