Ecology and evolution of Mycobacterium tuberculosis
S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …
The causative agents of TB are a group of closely related bacteria known as the …
Pathogenicity and virulence of Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …
known about the niche width of obligate human pathogens. Here we analyzed a global …
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
JCS Ngabonziza, C Loiseau, M Marceau… - Nature …, 2020 - nature.com
The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes
Background: The Global Typhoid Genomics Consortium was established to bring together
the typhoid research community to aggregate and analyse Salmonella enterica serovar …
the typhoid research community to aggregate and analyse Salmonella enterica serovar …
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid …
Background Improved genetic understanding of Mycobacterium tuberculosis (MTB)
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
resistance to novel and repurposed anti-tubercular agents can aid the development of rapid …
Robust barcoding and identification of Mycobacterium tuberculosis lineages for epidemiological and clinical studies
G Napier, S Campino, Y Merid, M Abebe… - Genome medicine, 2020 - Springer
Background Tuberculosis, caused by bacteria in the Mycobacterium tuberculosis complex
(MTBC), is a major global public health burden. Strain-specific genomic diversity in the …
(MTBC), is a major global public health burden. Strain-specific genomic diversity in the …
Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
F Coll, R McNerney, MD Preston… - Genome medicine, 2015 - Springer
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …
control. Current molecular tests examine limited numbers of mutations, and although whole …
Assessment of epidemiological and genetic characteristics and clinical outcomes of resistance to bedaquiline in patients treated for rifampicin-resistant tuberculosis: a …
Background Bedaquiline improves outcomes of patients with rifampicin-resistant and
multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this …
multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this …