Thrombosis is the most frequent cause of mortality worldwide and is closely linked to
haemostasis, which is the biological mechanism that stops bleeding after the injury of blood …

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in
organisms ranging from slime molds to mammals. Central to their function is their ability to …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

In recent years, the traditional view of the hemostatic system as being regulated by a
coagulation factor cascade coupled with platelet activation has been increasingly …

Blood contains microparticles (MPs) derived from a variety of cell types, including platelets,
monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs …

Stem cells are critical to maintaining steady-state organ homeostasis and regenerating
injured tissues. Recent intriguing reports implicate extracellular vesicles (EVs) as carriers for …

Mechanisms of Thrombus Formation | New England Journal of Medicine Skip to main content
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When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Cancer patients are at an increased risk of developing thromboembolic complications.
Several mechanisms have been proposed to explain cancer-associated thrombosis …

Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries,
especially in the elderly. Many risk factors have been identified for venous thrombosis that …