Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …
their native functional states into intractable amyloid aggregates. This phenomenon is …
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF
Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …
The road to restoring neural circuits for the treatment of Alzheimer's disease
Alzheimer's disease is a progressive loss of memory and cognition, for which there is no
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's …
Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset
D Petit, SG Fernández, KM Zoltowska, T Enzlein… - Molecular …, 2022 - nature.com
Familial Alzheimer's disease (FAD), caused by mutations in Presenilin (PSEN1/2) and
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
Amyloid Precursor Protein (APP) genes, is associated with an early age at onset (AAO) of …
[HTML][HTML] Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease
RA Nixon - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …
Genes associated with Alzheimer's disease: an overview and current status
M Giri, M Zhang, Y Lü - Clinical interventions in aging, 2016 - Taylor & Francis
Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most
common form of dementia in elderly people. It is an emerging public health problem that …
common form of dementia in elderly people. It is an emerging public health problem that …
Targeting amyloidogenic processing of APP in Alzheimer's disease
Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
CR Muratore, HC Rice, P Srikanth… - Human molecular …, 2014 - academic.oup.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by
extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing …
extracellular plaques containing amyloid β (Aβ)-protein and intracellular tangles containing …
Alzheimer's disease: etiology, neuropathology and pathogenesis
O Sheppard, M Coleman - Exon Publications, 2020 - exonpublications.com
Alzheimer's disease is the most common form of dementia and the most common
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …
neurodegenerative disease. It manifests as a decline in short-term memory and cognition …