Over the past several decades the traditional view of cancer being a homogeneous mass of
rapid proliferating malignant cells is being replaced by a model of ever increasing …

The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

Because of high heterogeneity, molecular characterization of prostate cancer based on
biopsy sampling is often challenging. Hence, a minimally invasive method to determine the …

The epidermal growth factor receptor (EGFR) family comprehends four different tyrosine
kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following binding to …

The epidermal growth factor receptor (EGFR) is activated by many ligands and belongs to a
family of tyrosine kinase receptors, including ErbB2, ErbB3, and ErbB4. These receptors are …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Epithelial–mesenchymal transition (EMT) is an important contributor to the invasion and
metastasis of epithelial-derived cancers. While considerable effort has focused in the …

Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin.
As carcinomas progress, these tumors may lose epithelial morphology and acquire …

Members of the epidermal growth factor receptor (EGFR/ErbB) family play a critical role in
normal cell growth and development. However, many ErbB family members, especially …

Metastasis is a multi-step process wherein tumour cells detach from the primary mass,
migrate through barrier matrices, gain access to conduits to disseminate, and subsequently …