Surviving a given infection requires the generation of a controlled immune response. Failure
to establish or restore homeostatic conditions during or following the onset of an infection …

Each microenvironment requires a specific set of regulatory elements that are finely and
constantly tuned to maintain local homeostasis. Various populations of regulatory T cells …

Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is
associated with rural environments and agricultural activities. However, the incidence and …

Abstract Forkheadbox protein 3 (FOXP3), initially identified as a key transcription factor for
regulatory T cells (Treg cells), was also expressed in many tumors including pancreatic …

Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to
inflammation and malignant progression. In this study, we show that CCL5 plays a critical …

Only a handful of the more than 100,000 fungal species on our planet cause disease in
humans, yet the number of life-threatening fungal infections in patients has recently …

Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila‐
Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in …

Paracoccidioidomycosis (PCM) is a systemic mycosis with a high incidence in Latin
America. Prior studies have demonstrated the significance of the enzyme Indoleamine 2, 3 …

We review here the advances in the understanding of the immunopathology of human
paracoccidioidomycosis (PCM). Its investigation must take in account the intriguing natural …