Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …

The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health
concern, and new treatment strategies are needed. Targeting inflammatory innate immunity …

Evidence of micro-and macro-thrombi in the arteries and veins of critically ill COVID-19
patients and in autopsies highlight the occurrence of COVID-19-associated coagulopathy …

The coagulation, fibrinolytic, anticoagulation, and complement systems are in delicate
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …

Tissue factor (TF) is a procoagulant protein released from activated host cells, such as
monocytes, and tumor cells on extracellular vesicles (EVs). TF+ EVs are observed in the …

BACKGROUND: Thrombo-inflammation is central to COVID-19-associated coagulopathy. TF
(tissue factor), a driver of disordered coagulation and inflammation in viral infections, may be …

Tissue factor (TF) is induced in a variety of cell types during viral infection, which likely
contributes to disseminated intravascular coagulation and thrombosis. TF‐expressing cells …