Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

[HTML][HTML] Pleotropic effects of polyphenols in cardiovascular system

T Behl, S Bungau, K Kumar, G Zengin, F Khan… - Biomedicine & …, 2020 - Elsevier
Numerous epidemiological and clinical studies demonstrate the beneficial effects of
naturally occurring, polyphenol supplementations, on cardiovascular system. The present …

[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets

DP Ramji, TS Davies - Cytokine & growth factor reviews, 2015 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …

Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis

AB Santhakumar, M Battino… - Food and Chemical …, 2018 - Elsevier
Epidemiological studies have demonstrated that nutritional habits, like those based on high
consumption of fruits and vegetables, have been associated with a longer life expectancy …

Nutraceutical therapies for atherosclerosis

JWE Moss, DP Ramji - Nature Reviews Cardiology, 2016 - nature.com
Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries and is
considered to be a major underlying cause of cardiovascular disease (CVD). Although the …

Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications

R Meshkani, S Vakili - Clinica chimica acta, 2016 - Elsevier
There is increasing evidence showing that chronic inflammation is an important pathogenic
mediator of the development of type 2 diabetes (T2D). It is now generally accepted that …

An inflammation classification system using cytokine parameters

K Roe - Scandinavian journal of immunology, 2021 - Wiley Online Library
Inflammation can be created by several different causes, including a blood clot, an immune
system disorder, a cancer, an infection, a chemical exposure, a physical injury, or a …

Cytokines: roles in atherosclerosis disease progression and potential therapeutic targets

JWE Moss, DP Ramji - Future medicinal chemistry, 2016 - Taylor & Francis
Atherosclerosis, the primary cause of cardiovascular disease (CVD), is a chronic
inflammatory disorder in the walls of medium and large arteries. CVD is currently …

A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence

M Jiang, MCW Huizenga, JL Wirt, J Paloczi… - Nature …, 2023 - nature.com
Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG)
and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical …

[HTML][HTML] Nutraceuticals as therapeutic agents for atherosclerosis

JWE Moss, JO Williams, DP Ramji - … Acta (BBA)-Molecular Basis of Disease, 2018 - Elsevier
Atherosclerosis, a chronic inflammatory disorder of medium and large arteries and an
underlying cause of cardiovascular disease (CVD), is responsible for a third of all global …