HDAC6 as privileged target in drug discovery: A perspective
Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …
physiological functions. Besides histone modification, largely due to its cytoplasmic …
The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
Post-translational protein acetylation: an elegant mechanism for bacteria to dynamically regulate metabolic functions
Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …
to an existing proteome. The large number of known PTMs highlights the many ways that …
HDAC inhibitors in acute myeloid leukemia
E San José-Enériz, N Gimenez-Camino, X Agirre… - Cancers, 2019 - mdpi.com
Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …
Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
RW Johnstone - Nature reviews Drug discovery, 2002 - nature.com
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
Targeting epigenetics for cancer therapy
JW Park, JW Han - Archives of pharmacal research, 2019 - Springer
Cancer can be identified as a chaotic cell state, which breaks the rules that govern growth
and reproduction, with main characteristics such as uncontrolled division, invading other …
and reproduction, with main characteristics such as uncontrolled division, invading other …
Cardiac metabolism in HFpEF: from fuel to signalling
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
energy substrates. Among the different types of HF, HF with preserved ejection fraction …
[HTML][HTML] HDAC‐6 interacts with and deacetylates tubulin and microtubules in vivo
Y Zhang, N Li, C Caron, G Matthias, D Hess… - The EMBO …, 2003 - embopress.org
Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …
which are involved in a great variety of cellular processes. Reversible acetylation on the ϵ …
Inhibitors of histone deacetylase as antitumor agents: A critical review
M Manal, MJN Chandrasekar, JG Priya, MJ Nanjan - Bioorganic chemistry, 2016 - Elsevier
Abstract Histone deacetylase (EC 3.5. 1.98–HDAC) is an amidohydrolase involved in
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …
deacetylating the histone lysine residues for chromatin remodeling and thus plays a vital …
[HTML][HTML] The key role of DNA methylation and histone acetylation in epigenetics of atherosclerosis
HT Lee, S Oh, H Yoo, YW Kwon - Journal of lipid and …, 2020 - ncbi.nlm.nih.gov
Atherosclerosis, which is the most common chronic disease of the coronary artery,
constitutes a vascular pathology induced by inflammation and plaque accumulation within …
constitutes a vascular pathology induced by inflammation and plaque accumulation within …