Discovering cellular protein‐protein interactions: Technological strategies and opportunities
K Titeca, I Lemmens, J Tavernier… - Mass spectrometry …, 2019 - Wiley Online Library
The analysis of protein interaction networks is one of the key challenges in the study of
biology. It connects genotypes to phenotypes, and disruption often leads to diseases …
biology. It connects genotypes to phenotypes, and disruption often leads to diseases …
From classical to new generation approaches: An excursus of-omics methods for investigation of protein-protein interaction networks
I Iacobucci, V Monaco, F Cozzolino, M Monti - Journal of proteomics, 2021 - Elsevier
Functional Proteomics aims to the identification of in vivo protein-protein interaction (PPI) in
order to piece together protein complexes, and therefore, cell pathways involved in …
order to piece together protein complexes, and therefore, cell pathways involved in …
DRP1 interacts directly with BAX to induce its activation and apoptosis
A Jenner, A Peña‐Blanco, R Salvador‐Gallego… - The EMBO …, 2022 - embopress.org
The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at
mitochondria during apoptosis to mediate mitochondrial permeabilization and …
mitochondria during apoptosis to mediate mitochondrial permeabilization and …
Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4
Many polyubiquitinated proteins are extracted from membranes or complexes by the
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Abstract The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part
through establishing repressive heterochromatin at transposon loci. Silencing requires …
through establishing repressive heterochromatin at transposon loci. Silencing requires …
Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System
The type IX secretion system (T9SS) has been recently discovered and is specific to
Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis …
Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis …
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers
Chemical cross-linking of proteins coupled with mass spectrometry analysis (CXMS) is
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
widely used to study protein-protein interactions (PPI), protein structures, and even protein …
The molecular architecture of native BBSome obtained by an integrated structural approach
HT Chou, L Apelt, DP Farrell, SR White, J Woodsmith… - Structure, 2019 - cell.com
The unique membrane composition of cilia is maintained by a diffusion barrier at the
transition zone that is breached when the BBSome escorts signaling receptors out of cilia …
transition zone that is breached when the BBSome escorts signaling receptors out of cilia …
A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria
A Linden, M Deckers, I Parfentev, R Pflanz… - Molecular & Cellular …, 2020 - ASBMB
Protein cross-linking and the analysis of cross-linked peptides by mass spectrometry is
currently receiving much attention. Not only is this approach applied to isolated complexes …
currently receiving much attention. Not only is this approach applied to isolated complexes …
Identification and characterization of protein cross-links induced by oxidative reactions
Introduction: Protein cross-links are common in biological systems and are generated both
deliberately as a part of normal metabolism and also accidently as a result of exposure to …
deliberately as a part of normal metabolism and also accidently as a result of exposure to …