Advances in culture-independent research techniques have led to an increased
understanding of the gut microbiota and the role it plays in health and disease. The intestine …

Inflammatory bowel disease (IBD) is a chronic immune-mediated disease affecting the
gastrointestinal tract. IBD consists of 2 subtypes: ulcerative colitis and Crohn disease. IBD is …

Objective We aimed to provide an evidence-supported update of the ECCO-ESPGHAN
guideline on the medical management of paediatric Crohn's disease [CD]. Methods We …

The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

Background Ulcerative colitis is a chronic inflammatory bowel disease with an estimated 150
000 patients in Germany alone. Methods This review is based on publications about current …

Developments in high-throughput microbial genomic sequencing and other systems biology
techniques have given novel insight into the potential contribution of the gut microbiota to …

Overweight, obesity, undernutrition and their respective sequelae have devastating tolls on
personal and public health worldwide. Traditional approaches for treating these conditions …

Bile acids are a group of chemically different steroids generated at the host/microbial
interface. Indeed, while primary bile acids are the end-product of cholesterol breakdown in …

Abstract The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct
contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to …

The human microbiome research is with the notable exception of fecal transplantation still
mostly in a descriptive phase. Part of the difficulty for translating research into medical …