The liver serves a spectrum of essential metabolic and synthetic functions that are required
for the transition from fetal to postnatal life. Processes essential to the attainment of …

In mammalian cells, amino acids affect the phosphorylation state and function of several
proteins involved in mRNA translation that are regulated via the rapamycin-sensitive mTOR …

Psychological stress has extreme adverse consequences on health. However, the molecular
mechanisms that mediate and accelerate the process of aging due to stress hormone are …

Signaling through the target of rapamycin is required for increased protein synthesis, cell
growth, and proliferation in response to growth factors. However, the downstream mediators …

Scope: Autophagy (type II programmed cell death) is crucial for maintaining cellular
homeostasis. Several autophagy‐deficient or knockout studies indicate that autophagy is a …

Abstract The mammalian Target Of Rapamycin (mTOR) is a nutrient‐sensing protein kinase
that regulates numerous cellular processes. Fetal rat metatarsal explants were used as a …

A series of novel, highly potent, selective, and ATP-competitive mammalian target of
rapamycin (mTOR) inhibitors based on a benzoxazepine scaffold have been identified. Lead …

Juvenile rainbow trout (Oncorhynchus mykiss) confined in pairs form social hierarchies in
which socially subordinate fish display characteristic traits, including reduced growth rates …

Abstract Background Ribosomal protein S6 (rpS6), a component of the 40S ribosomal
subunit, is involved in multiple cellular bioactivities. However, its clinicopathological …

The mechanisms by which amino acids regulate the cell cycle are not well characterized. In
this study, we examined the control of hepatocyte proliferation by amino acids and protein …