Comparison of antibiotic resistance mechanisms in antibiotic-producing and pathogenic bacteria

H Ogawara - Molecules, 2019 - mdpi.com
Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

Mycobacterial cell wall: a source of successful targets for old and new drugs

C Vilchèze - Applied Sciences, 2020 - mdpi.com
Eighty years after the introduction of the first antituberculosis (TB) drug, the treatment of drug-
susceptible TB remains very cumbersome, requiring the use of four drugs (isoniazid …

Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance

ES Kavvas, E Catoiu, N Mih, JT Yurkovich… - Nature …, 2018 - nature.com
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …

[图书][B] Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance

World Health Organization - 2023 - books.google.com
Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

[PDF][PDF] Optimized broth microdilution plate methodology for drug susceptibility testing of Mycobacterium tuberculosis complex

World Health Organization - 2022 - apps.who.int
Under the terms of this licence, you may copy, redistribute and adapt the work for non-
commercial purposes, provided the work is appropriately cited, as indicated below. In any …

[HTML][HTML] Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall

SM Batt, CE Burke, AR Moorey, GS Besra - The Cell Surface, 2020 - Elsevier
Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …

d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal

D Deshpande, JWC Alffenaar, CU Köser… - Clinical Infectious …, 2018 - academic.oup.com
Background d-cycloserine is used to treat multidrug-resistant tuberculosis. Its efficacy,
contribution in combination therapy, and best clinical dose are unclear, also data on the d …

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

M Merker, TA Kohl, I Barilar, S Andres, PW Fowler… - Genome Medicine, 2020 - Springer
Background A comprehensive understanding of the pre-existing genetic variation in genes
associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is …

Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

D Evangelopoulos, GA Prosser, A Rodgers… - Nature …, 2019 - nature.com
Drug resistant infections represent one of the most challenging medical problems of our
time. d-cycloserine is an antibiotic used for six decades without significant appearance and …

Perspectives for personalized therapy for patients with multidrug‐resistant tuberculosis

C Lange, WA Alghamdi, MH Al‐Shaer… - Journal of internal …, 2018 - Wiley Online Library
Abstract According to the World Health Organization (WHO), tuberculosis is the leading
cause of death attributed to a single microbial pathogen worldwide. In addition to the large …