Rationale Psychosocial stressors are a well-documented risk factor for mental illness.
Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect
hundreds of millions of individuals worldwide. Understanding the etiology and related …

Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …

The concept that intestinal microbial composition not only affects the health of the gut, but
also influences centrally-mediated systems involved in mood, is supported by a growing …

In some patients with major depressive disorder (MDD), individual illness characteristics
appear consistent with those of a neuroprogressive illness. Features of neuroprogression …

Psychosocial stress is associated with altered immune function and development of
psychological disorders including anxiety and depression. Here we show that repeated …

Acute and chronic stress sensitizes or “primes” the neuroinflammatory response to a
subsequent pro-inflammatory challenge. While prior evidence shows that glucocorticoids …

Idiopathic Parkinson's disease (PD) represents a complex interaction between the inherent
vulnerability of the nigrostriatal dopaminergic system, a possible genetic predisposition, and …

Children exposed to abuse or neglect show abnormal hippocampal development and
similar findings have been reported in rodent models. Using brief daily separation (BDS), a …