Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Most cancer patients are treated with radiotherapy, but the treatment can also damage the
surrounding normal tissue. Radiotherapy side-effects diminish patients' quality of life, yet …

Ionizing radiation primarily perturbs the basic molecular level proportional to dose, with
potential damage propagation to higher levels: cells, tissues, organs, and whole body. There …

The risk of radionuclide release in terrorist acts or exposure of healthy tissue during
radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell …

Lesions to DNA trigger the DNA-damage response (DDR), a complex, multi-branched cell-
intrinsic process targeted to DNA repair, or elimination of the damaged cells by apoptosis …

DNA is the cellular target that has the most damage induced by ionizing radiation (IR). If
genomic instability resulting from this DNA damage is not correctly repaired, it leads to …

Ionizing radiation exposure is harmful and at high doses can lead to acute hematopoietic
radiation syndrome. Therefore, agents that can protect hematopoietic system are important …

A genetic screen using a library of 6,961 siRNAs led to the identification of SHP-1 (PTPN6),
a tumor suppressor frequently mutated in malignant lymphomas, leukemias, and prostate …

Background: Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced
formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because …

The deep space environment contains many risks to astronauts during space missions, such
as galactic cosmic rays (GCRs) comprised of naturally occurring heavy ions. Heavy ion …