The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …

Biological ageing is generally accompanied by a gradual loss of cellular functions and
physiological integrity of organ systems, the consequential enhancement of vulnerability …

Sarcopenia is an important public health problem, characterized by age-related loss of
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on
somatic growth, metabolism, and tissue repair, and have been implicated in aging and …

Chimeric genes were constructed by fusing of human GH (hGH) cDNA to one, two, or three
cassettes of the carboxyl-terminal peptide (CTP) of human chorionic gonadotropin (hCG)-β …

Background To determine the association of the A55T and K153R polymorphisms of the
Myostatin gene with obesity, abdominal obesity and lean body mass (LBM) in Asian Indians …

This review intends to provide the reader with a practical overview of several (patho)
physiological conditions in which knowledge of the interplay between growth hormone (GH) …

A unique mouse model was developed with elevated endogenous GH (2-to 3-fold) and IGF-I
(1.2-to 1.4-fold), due to somatotrope-specific Cre-mediated inactivation of IGF-I receptor …

GH deficiency is thought to be involved in the pathogenesis of amyotrophic lateral sclerosis
(ALS). However, therapy with GH and/or IGF-I has not shown benefit. To gain a better …

Obesity is a chronic pathological condition with a multifactorial aetiology, characterised by
an excessive body fat accumulation with multiple organ-specific consequences. Emerging …