Despite tremendous efforts in basic research and a growing number of clinical trials aiming
to find effective treatments, amyotrophic lateral sclerosis (ALS) remains an incurable …

Background: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of
upper (UMN) and lower motor neurons (LMN) in four different body regions (bulbar, cervical …

Cumulative data suggest that neuroinflammation plays a prominent role in amyotrophic
lateral sclerosis (ALS) pathogenesis. The purpose of this work was to assess if patients with …

Background Neuroanatomical staging of sporadic amyotrophic lateral sclerosis (ALS)
indicates that neurodegeneration may spread corticofugally. Methods We conducted an …

Objective To assess the performance of serum neurofilament light chain (sNfL) in clinical
phenotypes of amyotrophic lateral sclerosis (ALS). Methods In 2949 ALS patients at 16 ALS …

Introduction Knee osteoarthritis is the common joint disease and one of the major causes of
pain and disability in the world. Regarding the people tendency to traditional medicine the …

Background Several studies have reported disproportionate wasting of the flexor muscles of
the lower limbs (LL) compared to the extensors in patients with amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease
characterised by the loss of motor control. Current understanding of ALS pathology is largely …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving motor neuron
(MN) loss in the motor cortex, brainstem and spinal cord leading to progressive paralysis …

Spreading of motor neuron degeneration in ALS is not so random. - Abstract - Europe PMC
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