Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …

Although monoaminergic antidepressants revolutionized the treatment of Major Depressive
Disorder (MDD) over a half-century ago, approximately one third of depressed patients …

Background: Individuals with major depressive disorder (MDD) vary in their response to
antidepressants. However, identifying objective biomarkers, prior to or early in the course of …

Objective: Observational studies show that when a depressed mother's symptoms remit, her
children's psychiatric symptoms decrease. Using randomized treatment assignment, the …

Objective: Combining antidepressants (ADs) for therapy of acute depression is frequently
employed, but randomized studies have yielded conflicting results. We conducted a …

Background Previous work suggests that major depressive disorder (MDD) is associated
with disturbances in global connectivity among brain regions, as well as local connectivity …

Background Task shifting approaches (rational redistribution of tasks among health
workforce teams) to train lay professionals to assist with integrating mental health treatment …

This article provides an updated review of the pharmacological profile and available efficacy
and tolerability/safety data for vilazodone, one of the most recent antidepressant drugs to be …

Objectives The purpose of this study is to use independent datasets to externally validate the
three symptom clusters of unipolar depression identified by Chekroud, to evaluate …