Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory" M1" macrophages. However, alternatively activated" M2" …

The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic,
whereas the microenvironment of tissues affected by chronic inflammatory disease is pro …