Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose
tissue, is a devastating complication of cancer and other chronic diseases. Interleukin-6 and …

Sarcopenia is a term utilized to define the loss of muscle mass and strength that occurs with
aging. Sarcopenia is believed to play a major role in the pathogenesis of frailty and …

Progressive wasting is common in many types of cancer and is one of the most important
factors leading to early death in cancer patients. Weight loss is a potent stimulus to food …

Diabetic neuropathy is the most common peripheral neuropathy in western countries.
Although every effort has been made to clarify the pathogenic mechanism of diabetic …

Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor
neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering …

Ciliary neurotrophic factor (CNTF) is a neuroactive cytokine found in Schwann cells, which
appears to be released in response to nerve injury. The ALS CNTF Treatment Study (ACTS) …

Prolonged production of cytokines associated with cancer and chronic infections, and other
long-term immune reactions is increasingly recognized as a main causal factor of the often …

Cytokines are a diverse family of intercellular signaling proteins that influence the
movement, proliferation, differentiation, metabolism and membrane processes of target cells …