Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Pattern recognition receptors in health and diseases

D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Cardiovascular considerations for patients, health care workers, and health systems during the COVID-19 pandemic

E Driggin, MV Madhavan, B Bikdeli, T Chuich… - Journal of the American …, 2020 - jacc.org
Abstract The coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 that has significant implications for the …

Transforming growth factor-β in myocardial disease

NG Frangogiannis - Nature Reviews Cardiology, 2022 - nature.com
Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

High thrombus burden in patients with COVID-19 presenting with ST-segment elevation myocardial infarction

FA Choudry, SM Hamshere, KS Rathod… - Journal of the American …, 2020 - jacc.org
Abstract Background Coronavirus disease-2019 (COVID-19) is thought to predispose
patients to thrombotic disease. To date there are few reports of ST-segment elevation …

Colchicine in patients with acute coronary syndrome: the Australian COPS randomized clinical trial

DC Tong, S Quinn, A Nasis, C Hiew… - Circulation, 2020 - Am Heart Assoc
Background: Inflammation plays a crucial role in clinical manifestations and complications of
acute coronary syndromes (ACS). Colchicine, a commonly used treatment for gout, has …

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Investigation of the associations of novel inflammatory biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the …

EA Dziedzic, JS Gąsior, A Tuzimek, J Paleczny… - International Journal of …, 2022 - mdpi.com
Atherosclerosis, the underlying cause of coronary artery disease (CAD), has a significant
inflammatory component. White blood cell count is an affordable and accessible way to …

Oxidative stress-induced endothelial dysfunction in cardiovascular diseases

A Shaito, K Aramouni, R Assaf, A Parenti, A Orekhov… - 2022 - qspace.qu.edu.qa
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

AMP-activated protein kinase: the current landscape for drug development

GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …