Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

E Pérez-Herrero, A Fernández-Medarde - European journal of …, 2015 - Elsevier
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Polymeric nanoparticles for targeted drug delivery system for cancer therapy

F Masood - Materials Science and Engineering: C, 2016 - Elsevier
A targeted delivery system based on the polymeric nanoparticles as a drug carrier
represents a marvelous avenue for cancer therapy. The pivotal characteristics of this system …

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

Polymeric nanoparticles for targeted treatment in oncology: current insights

RH Prabhu, VB Patravale, MD Joshi - International journal of …, 2015 - Taylor & Francis
Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the
cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and …

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

J Nicolas, S Mura, D Brambilla, N Mackiewicz… - Chemical Society …, 2013 - pubs.rsc.org
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …

[HTML][HTML] Biomimetic nanoparticles for inflammation targeting

K Jin, Z Luo, B Zhang, Z Pang - Acta Pharmaceutica Sinica B, 2018 - Elsevier
There have been many recent exciting developments in biomimetic nanoparticles for
biomedical applications. Inflammation, a protective response involving immune cells, blood …

Recent advances in “smart” delivery systems for extended drug release in cancer therapy

RV Kalaydina, K Bajwa, B Qorri, A Decarlo… - International journal …, 2018 - Taylor & Francis
Advances in nanomedicine have become indispensable for targeted drug delivery, early
detection, and increasingly personalized approaches to cancer treatment. Nanoparticle …

The mechanisms of drug release in poly (lactic-co-glycolic acid)-based drug delivery systems—A review

S Fredenberg, M Wahlgren, M Reslow… - International journal of …, 2011 - Elsevier
Abstract Poly (d, l-lactic-co-glycolic acid)(PLGA) is the most frequently used biodegradable
polymer in the controlled release of encapsulated drugs. Understanding the release …

Recent advances in the surface functionalization of PLGA-based nanomedicines

MM El-Hammadi, JL Arias - Nanomaterials, 2022 - mdpi.com
Therapeutics are habitually characterized by short plasma half-lives and little affinity for
targeted cells. To overcome these challenges, nanoparticulate systems have entered into …