Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …

As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking
to the plasma membrane of dopaminergic neurons. In the present study, we examined …

Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of
neuron cells and, as a result, produces the high and induces DAT trafficking to plasma …

Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an
important biomarker of cocaine exposure. Depending on cocaine amount in‐taken, one …

Background Majority of cocaine users also consume alcohol, and concurrent use of cocaine
and alcohol produces cocaethylene, norcocaine, norcocaethylene, and other non-toxic …

It is a grand challenge to develop a truly effective treatment of substance use disorder
(SUD), particularly for cocaine and other drugs without an FDA-approved treatment …

It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …