The emerging link between cancer, metabolism, and circadian rhythms

S Masri, P Sassone-Corsi - Nature medicine, 2018 - nature.com
The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …

Roles of circadian clocks in cancer pathogenesis and treatment

Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity

H Chi, J Yang, G Peng, J Zhang, G Song, X Xie… - Frontiers in …, 2023 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC) is the most common head
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …

[HTML][HTML] Circadian rhythm disruption promotes lung tumorigenesis

T Papagiannakopoulos, MR Bauer, SM Davidson… - Cell metabolism, 2016 - cell.com
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in
living systems, including two hallmarks of cancer, cell division and metabolism. Circadian …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

Cancer and the circadian clock

AA Shafi, KE Knudsen - Cancer research, 2019 - AACR
The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …

Circadian control of the immune system

C Scheiermann, Y Kunisaki, PS Frenette - Nature Reviews Immunology, 2013 - nature.com
Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …

BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress

M Xie, Q Tang, J Nie, C Zhang, X Zhou, S Yu… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic cardiovascular diseases are the leading cause of mortality
worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation …

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

R Hardeland, JA Madrid, DX Tan… - Journal of pineal …, 2012 - Wiley Online Library
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

[HTML][HTML] MYC disrupts the circadian clock and metabolism in cancer cells

BJ Altman, AL Hsieh, A Sengupta, SY Krishnanaiah… - Cell metabolism, 2015 - cell.com
The MYC oncogene encodes MYC, a transcription factor that binds the genome through
sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the …