The emerging link between cancer, metabolism, and circadian rhythms
S Masri, P Sassone-Corsi - Nature medicine, 2018 - nature.com
The circadian clock is a complex cellular mechanism that, through the control of diverse
metabolic and gene expression pathways, governs a large array of cyclic physiological …
metabolic and gene expression pathways, governs a large array of cyclic physiological …
Roles of circadian clocks in cancer pathogenesis and treatment
Y Lee - Experimental & molecular medicine, 2021 - nature.com
Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …
rhythms in cellular and bodily functions across nearly all living species. These internal clock …
Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity
H Chi, J Yang, G Peng, J Zhang, G Song, X Xie… - Frontiers in …, 2023 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC) is the most common head
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …
[HTML][HTML] Circadian rhythm disruption promotes lung tumorigenesis
T Papagiannakopoulos, MR Bauer, SM Davidson… - Cell metabolism, 2016 - cell.com
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in
living systems, including two hallmarks of cancer, cell division and metabolism. Circadian …
living systems, including two hallmarks of cancer, cell division and metabolism. Circadian …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
Cancer and the circadian clock
AA Shafi, KE Knudsen - Cancer research, 2019 - AACR
The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …
Circadian control of the immune system
C Scheiermann, Y Kunisaki, PS Frenette - Nature Reviews Immunology, 2013 - nature.com
Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …
emerging as important regulators of specific immune functions. Circadian oscillations of …
BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress
M Xie, Q Tang, J Nie, C Zhang, X Zhou, S Yu… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic cardiovascular diseases are the leading cause of mortality
worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation …
worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation …
Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling
Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …
[HTML][HTML] MYC disrupts the circadian clock and metabolism in cancer cells
The MYC oncogene encodes MYC, a transcription factor that binds the genome through
sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the …
sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the …