This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Strategies for the design of bi-or multifunctional drugs are reviewed. A distinction is made
between bifunctional drugs interacting in a monovalent fashion with two targets and ligands …

Among individuals with episodic migraine, the influence of excessive acute medication use
on the development of chronic migraine depends upon within-person characteristics (eg …

Migraine ranks among the world's 20 most disabling health problems [30], and is the most
common neurologic disorder in the developed countries, affecting over 30 million US …

Dietary bioactive peptides have been, among many functionalities, associated with immune
modulation and thereby may improve resolution of inflammation. The goals of this research …

Opioids, and more specifically μ-opioid receptor (MOR) agonists such as morphine, have
long been clinically used as therapeutics for severe pain states but often come with serious …

Peptide hormones and neurotransmitters are of central importance in most aspects of
intercellular communication and are involved in virtually all degenerative diseases. In this …

Abstract A library of 5-arylthiosubstituted 2-amino-4, 6-diaryl-3-cyano-4H-pyrans has been
synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade …

Constraining the conformation of flexible peptides is a proven strategy to increase potency,
selectivity, and metabolic stability. The focus has mostly been on constraining the backbone …

Twin and triplet drugs are defined as compounds that contain respectively two and three
pharmacophore components exerting pharmacological effects in a molecule. The twin drug …