Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

Despite improvements in glycaemic and blood pressure control, and the efficacy of renin–
angiotensin system (RAS) blockade for proteinuria reduction, diabetic nephropathy is the …

There is very limited human renal sodium gradient-dependent glucose transporter protein
(SGLT2) mRNA and protein expression data reported in the literature. The first aim of this …

In the existing stages of diabetic kidney disease (DKD), the first stage of DKD is called the
preclinical stage, characterized by glomerular hyperfiltration, an abnormally elevated …

Extracellular adenosine concentrations are regulated by a panel of membrane transporters
which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two …

Since the discovery of the myofibroblast over 50 years ago, much has been learned about its
role in wound healing and fibrosis. Its origin, however, remains controversial, with a number …

Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems
and frequently associated with severe clinical complications, such as diabetic …

Renal fibrosis is a common irreversible process of chronic kidney disease (CKD)
characterized by uncontrolled deposits of extracellular matrix, replacement of cellular …

Angiogenesis is critical to wound repair due to its role in providing oxygen and nutrients that
are required to support the growth and function of reparative cells in damaged tissues …

Aberrant ligand-independent G protein–coupled receptor constitutive activity has been
implicated in the pathophysiology of a number of cancers. The adenosine A2B receptor …