Leptin is a master regulator of energy balance and body adiposity. Additionally, leptin exerts
important control on glucose homeostasis, thermogenesis, autonomic nervous system and …

First seen as a storage organ, the white adipose tissue (WAT) is now considered as an
endocrine organ. WAT can produce an array of bioactive factors known as adipokines acting …

The mammalian brain stores and distinguishes among episodic memories, ie memories
formed during the personal experience, through a mechanism of pattern separation …

Receptors of leptin, the prototypical adipokine, are expressed throughout the cortex and
several other areas of the brain. Although typically studied for its role in energy intake and …

Leptin is well known as an important hormone in the central control of feeding behavior.
During development, fetuses and newborns are exposed to leptin and recent evidence has …

It is well documented that the hormone leptin plays a pivotal role in regulating food intake
and body weight via its hypothalamic actions. However, leptin receptors are expressed …

Leptin signaling has received considerable attention in the Alzheimer disease (AD) field.
Within the past decade, the peptide hormone has been demonstrated to attenuate tau …

Traditional models of appetite control have emphasised the role of parallel homeostatic and
hedonic systems, but more recently the distinction between independent homeostatic and …

Leptin, a hormone produced by adipocytes, provides signals to specific regions of the
hypothalamus to control energy homeostasis. However, the past decade of research has not …

Circulating hormones influence multiple aspects of hypothalamic development and play a
role in directing formation of neural circuits. Leptin is secreted by adipocytes and functions …