A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly
expanding list of human diseases, ranging from neurodegenerative diseases to aging and …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

ABSTRACT TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major
pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease
associated with protein misfolding and aggregation. Most cases are characterized by TDP …

Aging is associated with the accumulation of several types of damage: in particular, damage
to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that …

Maintaining functional protein homeostasis (proteostasis) is a constant challenge in the face
of limited protein-folding capacity, environmental threats, and aging. Cells have developed …

For all organisms promoting protein homeostasis is a high priority in order to optimize
cellular functions and resources. However, there is accumulating evidence that aging leads …

The non-reducing disaccharide trehalose has been long considered only as a reserve
carbohydrate. However, recent studies in yeast suggested that this osmolyte can protect …

Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the
misfolding of native cellular PrP C into the disease-associated form PrP Sc that accumulates …

Sequestration of misfolded proteins into distinct cellular compartments plays a pivotal role in
proteostasis and proteopathies. Cytoplasmic ubiquitinated proteins are sequestered by …